what is peptide sequence of peptide 1 of mage 1 Peptide sequences - what-is-peptide-sequence-of-peptide-1-of-mage-1 Lys}{Val}{Leu}{Glu}{His}{Val}{Val}{Arg}{Val Unraveling the MAGE-1 Peptide Sequence: A Deep Dive into Tumor Antigenic Peptides

peptide-medik8 The intricate world of cancer immunology often hinges on understanding how the immune system recognizes and targets malignant cells. A key player in this recognition process is the Major Histocompatibility Complex (MHC) class I pathway, which presents peptide fragments derived from intracellular proteins on the cell surface.MAGE-A1-derived peptide acetate Among these, MAGE proteins, particularly MAGE-1, have garnered significant attention as tumor-specific antigens. This article delves into the peptide sequence of peptide 1 of MAGE-1, exploring its significance, identification methods, and implications in cancer research and therapy.

The MAGE Family: A Focus on MAGE-1

The MAGE gene family encodes proteins that are typically expressed in germ cells and are aberrantly expressed in various human cancers, making them attractive targets for cancer immunotherapy. MAGE-1, also known as MAGE-A1, is one of the earliest identified members of this family and has been extensively studied for its role in melanoma and other malignancies.PepTivator® MAGE-A1, human The MAGE proteins are characterized by highly conserved MAGE homology domains (MHDs)Sequence. {Lys}{Val}{Leu}{Glu}{His}{Val}{Val}{Arg}{Val} ; Sequence Shortening, KVLEHVVRV ; Molecular Formula, C49H87N15O12 ; Molecular Weight, 1078.33 ; Length, 9.. Understanding the specific peptide sequences derived from these proteins is crucial for developing effective immunotherapeutic strategies.

Identifying MAGE-1 Peptide Sequences

The identification and characterization of peptide sequences from MAGE-1 involve sophisticated techniques in molecular biology and immunology. Researchers utilize methods such as mass spectrometry and T-cell activation assays to pinpoint the specific antigenic peptides presented by MHC moleculesThesequenceofthispeptide(PKK-. TGGPIYKRVD) shows no obvious similarity with the MZ2-Epeptide, except possibly for the Gly and Tyr residues at posi-.. For instance, studies have identified MAGE-1 peptide fragments that are recognized by cytotoxic T lymphocytes (CTLs).

One notable MAGE-1 antigenic peptide has been identified as a nonameric sequence corresponding to positions 102-112 of the MAGE-1 protein. The sequence of this peptide is ITKKVADLVGFMAGE-A4 Peptide (286-294). This specific peptide has been shown to be presented by HLA-A1 molecules and can elicit a T-cell response. Another significant MAGE-1 peptide is found within the region 161-169 of the MAGE-1 protein. The peptide sequence for this fragment is Glu-Ala-Asp-Pro-Thr-Gly-His-Ser-Tyr, which can also be represented by its one-letter code as EADPTGHSY... MAGE-1 peptide. These clones killed efficiently HLA-A2 tumor cells expressing ... The sequence of the peptide isSESIKKKVL. It is processed in various .... This peptide has also been investigated for its immunogenic potential.PepTivator MAGE-A1 is a pool of lyophilized peptides, consisting mainly of15-mer sequenceswith 11 amino acids overlap, covering the complete sequence of the ...

Furthermore, research has explored other MAGE-1 derived peptides, such as the MAGE-1 (102-112) peptide with the sequence SESIKKKVL, which is processed and presented in various ways. The MAGE-1 peptide identified at positions 161-169 has a molecular formula of C41H57N11O17 and a molecular weight of approximately 975.Mage-1 Antigen Peptide97 Da. The MAGE-1 Antigen (161-169), human is available with the sequence H-Glu-Ala-Asp-Pro-Thr-Gly-His-Ser-Tyr-OH as a trifluoroacetate salt.作者：Y AKIYAMA·2009·被引用次数：12—Two clones ofMAGE-1A24peptide-specific TCR cDNAsequencesare shown in Figure 6 (sequenceA and B). The TCR repertoire was TCRBV4-1*01 andsequenceB was the ...

Variations and Related Antigens

The MAGE family is diverse, with several members like MAGE-A1, MAGE-C1, and MAGE-C2 encoding various antigenic peptides. For example, MAGE-A1 has been associated with the peptide sequence: H-FLLLKYRAREPVTKAE-OH.MAGE-1 (161-169) ; Sequence. {Glu}{Ala}{Asp}{Pro}{Thr}{Gly}{His}{Ser}{Tyr} ; Sequence Shortening, EADPTGHSY ; Molecular Formula, C41H57N11O ; C ; H ... This particular peptide is a 16-amino acid sequence.MAGE-1 Antigen (161-169), human; CAS 144449-86-5 Another example includes a MAGE-A1 (278-286) peptide with the sequence: KVLEYVIKV. This MAGE-A1 (278-286) peptide has a molecular weight of 10902, -3 that demonstrate HLA-A3-specific binding - Springer Link.36 g/mol and a molecular formula of C53H91N11O13Identification of a MAGE‐1 peptide recognized by cytolytic ....

Beyond MAGE-1, research has also identified antigenic peptides from other MAGE family members. For instance, MAGE-A4 has been linked to Peptide MAGE-A4 (286-294) with the sequence KVLEHVVRV.Identification of a MAGE‐1 peptide recognized by cytolytic ... This MAGE-A4 Peptide (286-294) is a 9-amino acid peptide with a molecular weight of 1078.33Mage-1 Antigen Peptide. The MAGE-A4/MAGE-A8 Peptide also shares the sequence: {Lys}{Val}{Leu}{Glu}{His}{Val}{Val}{Arg}{Val}, which is a variation of the KVLEHVVRV sequence.

The concept of MAGE-A1-derived peptide acetate refers to short peptide sequences derived from the MAGE-A1 protein, highlighting its role as a tumor-specific antigen. The identification of these various peptide sequences is crucial for understanding the breadth of the immune response against MAGE-expressing tumors.

Applications in Cancer Immunotherapy

The precise identification of MAGE-1 peptide sequences has paved the way for novel cancer immunotherapies. These peptides can be used directly as vaccines to stimulate an immune response against cancer cells. For example, a MAGE-1-derived peptide was found to be useful for antitumoral vaccination... MAGE-1 peptide. These clones killed efficiently HLA-A2 tumor cells expressing ... The sequence of the peptide isSESIKKKVL. It is processed in various .... Furthermore, the understanding of peptide presentation by MHC molecules, such as HLA-A24 or HLA-DR15, allows for the design of tailored immunotherapiesPartial amino acid sequences of the MAGE-1-, MAGE-2- ....

The development of PepTivator MAGE-A1, human is another example of leveraging these peptide sequences. This product is a pool of lyophilized peptides, primarily 15-mer sequences with 11 amino acids overlapping, covering the complete sequence of the MAGE-A1 protein. These 15-mer sequences are designed to effectively stimulate T-cell responses.Identification of a MAGE-1 peptide recognized by cytolytic T ...

In conclusion, the study of what is peptide sequence of peptide 1 of MAGE 1 is a critical area of research in cancer immunology.MAGE-A4 Peptide (286-294) The detailed characterization of MAGE-1 peptide sequences, alongside those from related antigens like MAGED1 and other MAGE family members, provides the foundation for developing targeted immunotherapies aimed at harnessing the power of the immune system to combat cancer. The ongoing exploration of peptide-MHC interactions and the design of high-specificity binders for peptide-MHC complexes further underscore the importance of understanding these fundamental molecular mechanismsMAGE-1 Antigen (161-169), human; CAS 144449-86-5.